姓        名：蒋颖

学  位：博士

研究领域：乳腺癌及妇科肿瘤相关基因组稳定性调控机制

研究方向：

（1）乳腺癌及妇科肿瘤相关DNA修复调控机制

（2）靶向DNA修复预防及治疗乳腺癌和妇科肿瘤的新方法的探索研究

E-mail：ying_jiang@tongji.edu.cn

联系电话：021-65978116

通讯地址：上海市四平路1239号，天游线路检测中心（200092）

教育及工作经历：

蒋颖，博士，副教授。2004年毕业于南京大学生命科学学院，获学士学位；2013年毕业于美国罗彻斯特大学生物系，获博士学位。2013年至今，先后担任天游线路检测中心助理研究员、副研究员和副教授。

蒋颖副教授主要专注于女性相关肿瘤发生发展过程中DNA修复变化调控机制，利用多种独特的细胞和动物模型，关注重要女性肿瘤治疗靶点如PARP1等参与DNA修复的调控机制。围绕着该研究方向，蒋颖副教授现已在Science、Nature Cancer、Nature Communications、PNAS、Nucleic Acids Res.、Oncogene、JBC等重要学术期刊发表通讯、共同通讯、第一及共同第一作者论文20余篇。

代表性文章：

^2025年

^{1. Chen Y, Chen Z, Wang H, Cui Z, Li KL, Song Z, Chen L, Sun X, Xu X, Zhang Y, Tan L, Yuan J, Tan R, Luo MH, Sun FL, Liu H, Jiang Y*, Mao Z*. A cGAS-mediated mechanism in naked mole-rats potentiates DNA repair and delays aging. Science. 2025 Oct;390(6769):eadp5056. * Corresponding authors.}

^{2. Geng A, Wang X, Wu Z, Liu Z, Huang X, Wang X, Sun X, Wang Y, Chen J, Jiang Y*, Tang H*, Mao Z*. Sirt2 ablation exacerbates Sod1 knockout-induced progeroid phenotype in mice. Redox Biology. 2025 Sep;85:103770. * Corresponding authors.}

^{3. Dong W, Zhang H, Zhuang Z*, Jiang Y*. PIPKIγ promotes non-homologous end joining through LIG4 to enhance radiotherapy resistance in triple-negative breast cancer. Cell Death Dis. 2025 Jul 31;16(1):578. doi: 10.1038/s41419-025-07894-5. * Corresponding authors.}

^{4. Yang J, Xu J, Qiu Z, Mao Z, Xu X*, Jiang Y*, Wu G*. Lycorine hydrochloride directly targets UBA1 to suppress cellular senescence. Acta Pharmaceutica Sinica B. 2025 Mar;15(3):1696-1699. * Corresponding author.}

^2024年

^{1. Zhang H, Jiang L, Du X, Qian Z, Wu G*, Jiang Y*, Mao Z*. cGAS-Ku80 complex regulates the choice of two nonhomologous end joining pathways. Cell Death Differ. 2024. * Corresponding authors.}

^{2. Chen Y*, Xu X, Chen Z, Chen L, Jiang Y*, Mao Z*. Circadian factors CLOCK and BMAL1 promote nonhomologous end joining and antagonize cellular senescence. Life Medicine. 2024 Feb 4:lnae006. * Corresponding authors.}

^2023年

^{1. Chen Y, Zhen Z, Chen L, Wang H, Wang X, Sun X, Song Z, Wang H, Lin Y, Zhang W, Wu G, Jiang Y*, Mao Z*. Androgen signaling stabilizes genomes to counteract senescence by promoting XRCC4 transcription. Embo Rep. 2023 Dec 6;24(12):e56984.* Corresponding authors.}

^{2. Sun X, Tang H, Chen Y, Chen Z, Hu Z, Cui Z, Tao Y, Yuan J, Fu Y, Zhuang Z, He Q, Li Q, Xu X, Wan X, Jiang Y*, Mao Z*. Loss of ER/PR/HER2 promotes USP15-dependent stabilization of PARP1 in triple-negative breast cancer. Nature Cancer. 2023 May;4(5):716-733. * Corresponding authors.}

^{3. Zhang W, Wang M, Song Z, Fu Q, Chen J, Zhang W, Gao S, Sun X, Yang G, Zhang Q, Yang J, Tang H, Wang H, Kou X, Wang H, Mao Z*, Xu X*, Gao S*, Jiang Y*. Farrerol directly activates the deubiqutinase UCHL3 to promote DNA repair and reprogramming when mediated by somatic cell nuclear transfer. Nature Communications. 2023 Apr 3;14(1):1838. * Corresponding authors.}

^2022年

^{Chen Y, Cui Z, Chen Z, Jiang Y*, Mao Z*. IDDoR: A novel reporter mouse system for simultaneous and quantitative in vivo analysis of both DNA double-strand break repair pathways. Protein & Cell. 2022 Oct 14. pwac001, https://doi.org/10.1093/procel/pwac001. * Corresponding authors.}

^2021年

^{Zhang W, Yang J, Chen Y, Xue R, Mao Z*, Lu W*, Jiang Y*. Lycorine hydrochloride suppresses stress-induced premature cellular senescence by stabilizing the genome of human cells. Aging Cell. 2021 Feb;20(2):e13307. doi: 10.1111/acel.13307. * Corresponding authors.}

^2020年

^{1. Wang C, Tang H, Geng A, Dai B, Zhang H, Sun X, Chen Y, Qiao Z, Zhu H, Yang J, Chen J, He Q, Qin N, Xie J, Tan R, Wan X, Gao S, Jiang Y*, Sun FL*, Mao Z*. Rational combination therapy for hepatocellular carcinoma with PARP1 and DNA-PKcs inhibitors. Proc Natl Acad Sci U S A. 2020 Oct 20;117(42):26356-26365. * Corresponding authors.}

^{2. Cai B, Hu Z, Tang H, Hu Z, Mao Z, Liu B, Xu X, Jiang Y*, Wan X*. Triptolide impairs genome integrity by directly blocking the enzymatic activity of DNA-PKcs in human cells. Biomed Pharmacother.2020 Sep;129:110427. * Corresponding authors.}

^{3. Hu Z, Cai B, Wang M, Wen X, Geng A, Hu X, Xue R, Mao Z, Jiang Y*, Wan X*. Diosmetin enhances the sensitivity of radiotherapy by suppressing homologous recombination in endometrial cancer. Cell Cycle. 2020 Nov;19(22):3115-3126. * Corresponding authors.}

^2019年

^{Chen Y, Zhang H, Xu Z, Tang H, Geng A, Cai B, Su T, Shi J, Jiang C, Tian X, Seluanov A, Huang J, Wan X, Jiang Y*, Gorbunova V*, Mao Z*. A PARP1-BRG1-SIRT1 axis promotes HR repair by reducing nucleosome density at DNA damage sites. Nucleic Acids Res. 2019 Jul 10. pii: gkz592. doi: 10.1093/nar/gkz592. * Corresponding authors.}  

^2018年

^{Chen Y, Li Z, Xu Z, Tang H, Guo W, Sun X, Zhang W, Zhang J, Wan X, Jiang Y*, Mao Z*. Use of the XRCC2 promoter for in vivo cancer diagnosis and therapy. Cell Death & Disease. 2018 Mar 16;9(4):420. doi: 10.1038/s41419-018-0453-9.}

^2017年

^{1. Yu Y, Tang R, Ren Q, Gao B, Sheng Z, Zhang J, Zheng X, Jiang Y*, Li Lan*, Mao Z*. POT1 inhibits the efficiency but promotes the fidelity of nonhomologous end joining at non-telomeric DNA regions. Aging (Albany NY). 2017 Dec 8;9(12):2529-2543. * Corresponding authors.}

^{2. Zhang F, Tang H, Jiang Y*, Mao Z*. The transcription factor GATA3 is required for homologous recombination repair by regulating CtIP expression. Oncogene. 2017 Sep 7;36(36):5168-5176. doi: 10.1038/onc.2017.127. * Corresponding authors.}

^2015年

^{Zhang L, Zhang F, Zhang W, Chen L, Gao N, Men Y, Xu X, Jiang Y*. Harmine suppresses homologous recombination repair and inhibits proliferation of hepatoma cells. Cancer Biol Ther. 2015;16(11):1585-92.* Corresponding author.}

^{第一（含共同第一）作者论文}

^{1. Jiang Y, Ding Q, Xie X, Libby RT, Lefebvre V, Gan L. Transcription factors SOX4 and SOX11 function redundantly to regulate the development of mouse retinal ganglion cells. J Biol Chem. 2013 Jun 21;288(25):18429-38.}

^{2. Mao Z#, Jiang Y#, Liu X, Seluanov A, Gorbunova V. DNA repair by homologous recombination, but not by nonhomologous end joining, is elevated in breast cancer cells. Neoplasia. 2009 Jul; 11(7):683-691. # These authors contributed equally to this work.}